Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson’s disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our f...

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Detalhes bibliográficos
Main Authors: Braidy, Nady, Gai, Wei-Ping, Xu, Ying Hua, Sachdev, Perminder, Guillemin, Gilles J, Jiang, Xing-Mai, Ballard, J William O, Horan, Martin P, Fang, Zhi Ming, Chong, Beng H, Chan, Daniel Kam Yin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853407/
https://ncbi.nlm.nih.gov/pubmed/24093918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2047-9158-2-20
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