Effects of Kynurenine Pathway Metabolites on Intracellular NAD(+) Synthesis and Cell Death in Human Primary Astrocytes and Neurons

The kynurenine pathway (KP) is a major route of L-tryptophan catabolism resulting in the production of the essential pyridine nucleotide nicotinamide adenine dinucleotide, (NAD(+)). Up-regulation of the KP during inflammation leads to the release of a number of biologically active metabolites into t...

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Main Authors: Braidy, Nady, Grant, Ross, Brew, Bruce J, Adams, Seray, Jayasena, Tharusha, Guillemin, Gilles J.
Formato: Artigo
Idioma:Inglês
Publicado em: Libertas Academica 2009
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195228/
https://ncbi.nlm.nih.gov/pubmed/22084582
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