Secretory expression of biologically active human Herpes virus interleukin-10 analogues in Escherichia coli via a modified Sec-dependent transporter construct

BACKGROUND: Interleukin-10 homologues encoded by Herpes viruses such as Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) hold interesting structural and biological characteristics compared to human interleukin-10 (hIL-10) that render these proteins promising candidates for therapeutic appli...

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Bibliographic Details
Main Authors: Förster, Sarah, Brandt, Manuela, Mottok, Dorothea S, Zschüttig, Anke, Zimmermann, Kurt, Blattner, Frederick R, Gunzer, Florian, Pöhlmann, Christoph
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853369/
https://ncbi.nlm.nih.gov/pubmed/24093616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-13-82
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