Top3β is an RNA topoisomerase that works with Fragile X syndrome protein to promote synapse formation

Topoisomerases are crucial to solve DNA topological problems, but they have not been linked to RNA metabolism. Here we show that human topoisomerase 3β (Top3β) is an RNA topoisomerase that biochemically and genetically interacts with FMRP, a protein deficient in Fragile X syndrome and known to regul...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Xu, Dongyi, Shen, Weiping, Guo, Rong, Xue, Yutong, Peng, Wei, Sima, Jian, Yang, Jay, Sharov, Alexei, Srikantan, Subramanya, Yang, Jiandong, Fox, David, Qian, Yong, Martindale, Jennifer L., Piao, Yulan, Machamer, James, Joshi, Samit R., Mohanty, Subhasis, Shaw, Albert C., Lloyd, Thomas E., Brown, Grant W., Ko, Minoru S.H., Gorospe, Myriam, Zou, Sige, Wang, Weidong
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853347/
https://ncbi.nlm.nih.gov/pubmed/23912945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3479
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires