Crystal Structure and Site-directed Mutagenesis of 3-Ketosteroid Δ(1)-Dehydrogenase from Rhodococcus erythropolis SQ1 Explain Its Catalytic Mechanism*

3-Ketosteroid Δ(1)-dehydrogenases are FAD-dependent enzymes that catalyze the 1,2-desaturation of 3-ketosteroid substrates to initiate degradation of the steroid nucleus. Here we report the 2.0 Å resolution crystal structure of the 56-kDa enzyme from Rhodococcus erythropolis SQ1 (Δ(1)-KSTD1). The en...

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Autors principals: Rohman, Ali, van Oosterwijk, Niels, Thunnissen, Andy-Mark W. H., Dijkstra, Bauke W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853301/
https://ncbi.nlm.nih.gov/pubmed/24165124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522771
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