Meclizine Inhibits Mitochondrial Respiration through Direct Targeting of Cytosolic Phosphoethanolamine Metabolism

We recently identified meclizine, an over-the-counter drug, as an inhibitor of mitochondrial respiration. Curiously, meclizine blunted respiration in intact cells but not in isolated mitochondria, suggesting an unorthodox mechanism. Using a metabolic profiling approach, we now show that treatment wi...

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Hauptverfasser: Gohil, Vishal M., Zhu, Lin, Baker, Charli D., Cracan, Valentin, Yaseen, Abbas, Jain, Mohit, Clish, Clary B., Brookes, Paul S., Bakovic, Marica, Mootha, Vamsi K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Bioenergetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853286/
https://ncbi.nlm.nih.gov/pubmed/24142790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.489237
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