Discovery and therapeutic potential of drugs that shift energy metabolism from mitochondrial respiration to glycolysis

Most cells can dynamically shift their relative reliance on glycolytic versus oxidative metabolism in response to nutrient availability, during development, and in disease. Studies in model systems have shown that re-directing energy metabolism from respiration to glycolysis can suppress oxidative d...

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Main Authors: Gohil, Vishal M., Sheth, Sunil A., Nilsson, Roland, Wojtovich, Andrew P., Lee, Jeong Hyun, Perocchi, Fabiana, Chen, William, Clish, Clary B., Ayata, Cenk, Brookes, Paul S., Mootha, Vamsi K.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3135002/
https://ncbi.nlm.nih.gov/pubmed/20160716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1606
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