Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex

MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning mechanisms are not fully understood. We have shown recently that direct interaction between BUBR1 and MAD2 is critical for assembly and function of the human mitotic checkpoint complex (MCC), the SAC...

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Bibliographic Details
Main Authors: Tipton, Aaron R., Ji, Wenbin, Sturt-Gillespie, Brianne, Bekier, Michael E., Wang, Kexi, Taylor, William R., Liu, Song-Tao
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853266/
https://ncbi.nlm.nih.gov/pubmed/24151075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522375
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