Excitotoxic neuronal cell death during an oligodendrocyte-directed CD8(+) T cell attack in the CNS gray matter

BACKGROUND: Neural-antigen reactive cytotoxic CD8(+) T cells contribute to neuronal dysfunction and degeneration in a variety of inflammatory CNS disorders. Facing excess numbers of target cells, CNS-invading CD8(+) T cells cause neuronal cell death either via confined release of cytotoxic effector...

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Detalhes bibliográficos
Main Authors: Melzer, Nico, Hicking, Gordon, Bittner, Stefan, Bobak, Nicole, Göbel, Kerstin, Herrmann, Alexander M, Wiendl, Heinz, Meuth, Sven G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853237/
https://ncbi.nlm.nih.gov/pubmed/24093512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-10-121
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