N-benzyladriamycin-14-valerate (AD 198) exhibits potent anti-tumor activity on TRAF3-deficient mouse B lymphoma and human multiple myeloma

BACKGROUND: TRAF3, a new tumor suppressor identified in human non-Hodgkin lymphoma (NHL) and multiple myeloma (MM), induces PKCδ nuclear translocation in B cells. The present study aimed to evaluate the therapeutic potential of two PKCδ activators, N-Benzyladriamycin-14-valerate (AD 198) and ingenol...

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Detalhes bibliográficos
Main Authors: Edwards, Shanique K E, Moore, Carissa R, Liu, Yan, Grewal, Sukhdeep, Covey, Lori R, Xie, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853153/
https://ncbi.nlm.nih.gov/pubmed/24131623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-481
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