“Jumpstart and gain” model for dosage compensation in Drosophila based on direct sequencing of nascent transcripts

Dosage compensation in Drosophila is mediated by the MSL complex, which increases male X-linked gene expression approximately two-fold. The MSL complex preferentially binds the bodies of active genes on the male X, depositing H4K16ac with a 3′ bias. Two models have been proposed for the influence of...

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Main Authors: Ferrari, Francesco, Plachetka, Annette, Alekseyenko, Artyom A., Jung, Youngsook L., Ozsolak, Fatih, Kharchenko, Peter V., Park, Peter J., Kuroda, Mitzi I.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852897/
https://ncbi.nlm.nih.gov/pubmed/24183666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.09.037
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