Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs

BACKGROUND: Epidermal growth factor receptor- tyrosine kinase inhibitors (EGFR-TKIs) benefit Non-small cell lung cancer (NSCLC) patients, and an EGFR-TKIi erlotinib, is approved for patients with recurrent NSCLC. However, resistance to erlotinib is a major clinical problem. Earlier we have demonstra...

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Detalhes bibliográficos
Main Authors: Ahmad, Aamir, Maitah, Ma’in Y, Ginnebaugh, Kevin R, Li, Yiwei, Bao, Bin, Gadgeel, Shirish M, Sarkar, Fazlul H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852827/
https://ncbi.nlm.nih.gov/pubmed/24199791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-77
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