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Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs

BACKGROUND: Epidermal growth factor receptor- tyrosine kinase inhibitors (EGFR-TKIs) benefit Non-small cell lung cancer (NSCLC) patients, and an EGFR-TKIi erlotinib, is approved for patients with recurrent NSCLC. However, resistance to erlotinib is a major clinical problem. Earlier we have demonstra...

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Bibliografiset tiedot
Päätekijät:	Ahmad, Aamir, Maitah, Ma’in Y, Ginnebaugh, Kevin R, Li, Yiwei, Bao, Bin, Gadgeel, Shirish M, Sarkar, Fazlul H
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BioMed Central 2013
Aiheet:	Research
Linkit:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3852827/ https://ncbi.nlm.nih.gov/pubmed/24199791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-77
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Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAs

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