Decoy Oligonucleotide Rescues IGF1R Expression from MicroRNA-223 Suppression

A mature miRNA generally suppresses hundreds of mRNA targets. To evaluate the selective effect of synthetic oligonucleotide decoys on hsa-miR-223 activity, reporters containing 3’ untranslated regions (UTR) of IGF1R, FOXO1, POLR3G, FOXO3, CDC27, FBXW7 and PAXIP1 mRNAs were constructed for the lucife...

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Autores principales: Wu, Li Hui, Cai, Qian Qian, Dong, Yi Wei, Wang, Rong, He, Bao Mei, Qi, Bing, Xu, Chang Jun, Wu, Xing Zhong
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852755/
https://ncbi.nlm.nih.gov/pubmed/24324762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082167
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