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Evidence for small-molecule-mediated loop stabilization in the structure of the isolated Pin1 WW domain

The human Pin1 WW domain is a small autonomously folding protein that has been useful as a model system for biophysical studies of β-sheet folding. This domain has resisted previous attempts at crystallization for X-ray diffraction studies, perhaps because of intrinsic conformational flexibility tha...

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Main Authors: Mortenson, David E., Kreitler, Dale F., Yun, Hyun Gi, Gellman, Samuel H., Forest, Katrina T.
Formáid: Artigo
Teanga:Inglês
Foilsithe: International Union of Crystallography 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852655/
https://ncbi.nlm.nih.gov/pubmed/24311591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S090744491302444X
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