Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated FGFR3 si...

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Hauptverfasser: Matsushita, Masaki, Kitoh, Hiroshi, Ohkawara, Bisei, Mishima, Kenichi, Kaneko, Hiroshi, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Ohno, Kinji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852501/
https://ncbi.nlm.nih.gov/pubmed/24324705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081569
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