Meclozine Facilitates Proliferation and Differentiation of Chondrocytes by Attenuating Abnormally Activated FGFR3 Signaling in Achondroplasia

Achondroplasia (ACH) is one of the most common skeletal dysplasias with short stature caused by gain-of-function mutations in FGFR3 encoding the fibroblast growth factor receptor 3. We used the drug repositioning strategy to identify an FDA-approved drug that suppresses abnormally activated FGFR3 si...

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Hoofdauteurs: Matsushita, Masaki, Kitoh, Hiroshi, Ohkawara, Bisei, Mishima, Kenichi, Kaneko, Hiroshi, Ito, Mikako, Masuda, Akio, Ishiguro, Naoki, Ohno, Kinji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3852501/
https://ncbi.nlm.nih.gov/pubmed/24324705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081569
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