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Practical considerations for optimal designs in clinical dose finding studies
A key objective in the clinical development of a medicinal drug is the determination of an adequate dose level and, more broadly, the characterization of its dose response relationship. If the dose is set too high, safety and tolerability problems are likely to result, while selecting too low a dose...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3852432/ https://ncbi.nlm.nih.gov/pubmed/20213708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3802 |
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