Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells

BACKGROUND: Hypermethylation of the promoter of the tumor suppressor gene RASSF1A silences its expression and has been found to be associated with advanced grade prostatic tumors. The DNA methyltransferase (DNMT) family of enzymes are known to be involved in the epigenetic silencing of gene expressi...

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Hlavní autoři: Agarwal, Soumik, Amin, Karishma S, Jagadeesh, Shankar, Baishay, Gokul, Rao, Paruchuri G, Barua, Nabin C, Bhattacharya, Samir, Banerjee, Partha P
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851847/
https://ncbi.nlm.nih.gov/pubmed/24001151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-99
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