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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection force for cancer cell somatic evolution. Acidic pH has pleiotropic effects on...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3851830/ https://ncbi.nlm.nih.gov/pubmed/24367336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2013.00354 |
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