Role of K(ATP) Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

Glucagon, secreted by pancreatic islet α cells, is the principal hyperglycemic hormone. In diabetes, glucagon secretion is not suppressed at high glucose, exacerbating the consequences of insufficient insulin secretion, and is inadequate at low glucose, potentially leading to fatal hypoglycemia. The...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Quan, Ramracheya, Reshma, Lahmann, Carolina, Tarasov, Andrei, Bengtsson, Martin, Braha, Orit, Braun, Matthias, Brereton, Melissa, Collins, Stephan, Galvanovskis, Juris, Gonzalez, Alejandro, Groschner, Lukas N., Rorsman, Nils J.G., Salehi, Albert, Travers, Mary E., Walker, Jonathan N., Gloyn, Anna L., Gribble, Fiona, Johnson, Paul R.V., Reimann, Frank, Ashcroft, Frances M., Rorsman, Patrik
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851686/
https://ncbi.nlm.nih.gov/pubmed/24315372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2013.10.014
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