Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity

[Image: see text] Using Cu(I)-catalyzed azide-alkyne cycloaddition in a mixed classical organic phase and solid phase peptide synthesis approach, we synthesized four analogs of Leu-enkephalin to systematically replace amides by 1,4-disubstituted[1,2,3]triazoles. The peptidomimetics obtained were cha...

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Hlavní autoři: Proteau-Gagné, Arnaud, Rochon, Kristina, Roy, Mélissa, Albert, Pierre-Julien, Guérin, Brigitte, Gendron, Louis, Dory, Yves L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851295/
https://ncbi.nlm.nih.gov/pubmed/23988352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.08.020
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