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Exploring the Backbone of Enkephalins To Adjust Their Pharmacological Profile for the δ-Opioid Receptor
[Image: see text] The role of each of the four amide bonds in Leu(5)-enkephalin was investigated by systematically and sequentially replacing each with its corresponding trans-alkene. Six Leu(5)-enkephalin analogs based on six dipeptide surrogates and two Met(5)-enkephalin analogs were synthesized a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3368656/ https://ncbi.nlm.nih.gov/pubmed/22778812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn1000759 |
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