Ch14.18 antibody produced in CHO cells in relapsed or refractory Stage 4 neuroblastoma patients: A SIOPEN Phase 1 study

Purpose: This study aimed to assess the safety, pharmacokinetic and activity profiles of the human-mouse chimeric monoclonal anti-disialoganglioside GD2 antibody ch14.18 produced in Chinese hamster ovary (CHO) cells (ch14.18/CHO). Methods: Sixteen children with recurrent/refractory neuroblastoma (me...

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Detalhes bibliográficos
Main Authors: Ladenstein, Ruth, Weixler, Silke, Baykan, Bianca, Bleeke, Matthias, Kunert, Renate, Katinger, Dietmar, Pribill, Ingrid, Glander, Petra, Bauer, Steffen, Pistoia, Vito, Michon, Jean, Garaventa, Alberto, Lode, Holger N.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851232/
https://ncbi.nlm.nih.gov/pubmed/23924804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25215
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