Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies

TRU-016 is a SMIP(TM) (monospecific protein therapeutic) molecule against the tetraspanin transmembrane family protein CD37 that is currently in Phase 2 trials in Chronic Lymphocytic Leukemia (CLL) and Non-Hodgkin Lymphoma (NHL). In an attempt to enhance the ADCC function of SMIP-016, the chimeric v...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Rafiq, Sarwish, Siadak, Anthony, Butchar, Jonathan P., Cheney, Carolyn, Lozanski, Gerard, Jacob, Naduparambil K., Lapalombella, Rosa, McGourty, Jackie, Moledor, Meghan, Lowe, Richard, Setter, Ben, Jones, Jeffrey, Flynn, Joseph M., Andritsos, Leslie, Devine, Steven, Mo, Xiaokui, Jarjoura, David, Tridandapani, Susheela, Algate, Paul, Byrd, John C., Muthusamy, Natarajan
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2013
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3851225/
https://ncbi.nlm.nih.gov/pubmed/23883821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.25282
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky