A Polymorphism, R653Q, in the Trifunctional Enzyme Methylenetetrahydrofolate Dehydrogenase/Methenyltetrahydrofolate Cyclohydrolase/Formyltetrahydrofolate Synthetase Is a Maternal Genetic Risk Factor for Neural Tube Defects: Report of the Birth Defects Research Group

Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube defect (NTD) by >50%. A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C→T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion o...

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Autores principales: Brody, Lawrence C., Conley, Mary, Cox, Christopher, Kirke, Peadar N., McKeever, Mary P., Mills, James L., Molloy, Anne M., O’Leary, Valerie B., Parle-McDermott, Anne, Scott, John M., Swanson, Deborah A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Human Genetics 2002
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC385099/
https://ncbi.nlm.nih.gov/pubmed/12384833
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