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Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR
BACKGROUND: The t(6;9)(p23;q34) chromosomal translocation is found in 1% of acute myeloid leukemia and encodes the fusion protein DEK-NUP214 (formerly DEK-CAN) with largely uncharacterized functions. METHODS: We expressed DEK-NUP214 in the myeloid cell lines U937 and PL-21 and studied the effects on...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849736/ https://ncbi.nlm.nih.gov/pubmed/24073922 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-440 |
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