Intracytoplasmic Sperm Injection May Increase the Risk of Imprinting Defects

In germ cells and the early embryo, the mammalian genome undergoes widespread epigenetic reprogramming. Animal studies suggest that this process is vulnerable to external factors. We report two children who were conceived by intracytoplasmic sperm injection (ICSI) and who developed Angelman syndrome...

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Main Authors: Cox, Gerald F., Bürger, Joachim, Lip, Va, Mau, Ulrike A., Sperling, Karl, Wu, Bai-Lin, Horsthemke, Bernhard
Format: Artigo
Jezik:Inglês
Izdano: The American Society of Human Genetics 2002
Teme:
Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC384973/
https://ncbi.nlm.nih.gov/pubmed/12016591
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