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Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice
BACKGROUND: CR8 is a second generation inhibitor of cyclin-dependent kinases derived from roscovitine. CR8 was shown to be 50–100 fold more potent than roscovitine in inducing apoptosis in different tumor cell lines. In the present investigation, we have established an analytical method for the quan...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849647/ https://ncbi.nlm.nih.gov/pubmed/24079553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-14-50 |
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