Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice

BACKGROUND: CR8 is a second generation inhibitor of cyclin-dependent kinases derived from roscovitine. CR8 was shown to be 50–100 fold more potent than roscovitine in inducing apoptosis in different tumor cell lines. In the present investigation, we have established an analytical method for the quan...

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Bibliographic Details
Main Authors: Sallam, Hatem, El-Serafi, Ibrahim, Meijer, Laurent, Hassan, Moustapha
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849647/
https://ncbi.nlm.nih.gov/pubmed/24079553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-14-50
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