Optimization of the piggyBac Transposon Using mRNA and Insulators: Toward a More Reliable Gene Delivery System

Integrating and expressing stably a transgene into the cellular genome remain major challenges for gene-based therapies and for bioproduction purposes. While transposon vectors mediate efficient transgene integration, expression may be limited by epigenetic silencing, and persistent transposase expr...

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Bibliographic Details
Main Authors: Bire, Solenne, Ley, Déborah, Casteret, Sophie, Mermod, Nicolas, Bigot, Yves, Rouleux-Bonnin, Florence
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849487/
https://ncbi.nlm.nih.gov/pubmed/24312663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0082559
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