Classical swine fever virus triggers RIG-I and MDA5-dependent signaling pathway to IRF-3 and NF-κB activation to promote secretion of interferon and inflammatory cytokines in porcine alveolar macrophages

BACKGROUND: Classical swine fever (CSF) caused by CSF virus (CSFV) is a highly contagious disease of pigs. The RNA helicases retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA-5) are differentially involved in the detection of various RNA viruses. In present s...

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Hauptverfasser: Dong, Xiao-Ying, Liu, Wen-Jun, Zhao, Ming-Qiu, Wang, Jia-Ying, Pei, Jing-Jing, Luo, Yong-Wen, Ju, Chun-Mei, Chen, Jin-Ding
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849481/
https://ncbi.nlm.nih.gov/pubmed/24034559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-286
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