Live attenuated rubella vectors expressing SIV and HIV vaccine antigens replicate and elicit durable immune responses in rhesus macaques

BACKGROUND: Live attenuated viruses are among our most potent and effective vaccines. For human immunodeficiency virus, however, a live attenuated strain could present substantial safety concerns. We have used the live attenuated rubella vaccine strain RA27/3 as a vector to express SIV and HIV vacci...

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Hlavní autoři: Virnik, Konstantin, Hockenbury, Max, Ni, Yisheng, Beren, Joel, Pavlakis, George N, Felber, Barbara K, Berkower, Ira
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849444/
https://ncbi.nlm.nih.gov/pubmed/24041113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-10-99
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