Chemically and Biologically Synthesized CPP-Modified Gelonin for Enhanced Anti-tumor Activity

The ineffectiveness of small molecule drugs against cancer has generated significant interest in more potent macromolecular agents. Gelonin, a plant-derived toxin that inhibits protein translation, has attracted much attention in this regard. Due to its inability to internalize into cells, however,...

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Main Authors: Shin, Meong Cheol, Zhang, Jian, David, Allan E., Trommer, Wolfgang E., Kwon, Young Min, Min, Kyoung Ah, Kim, Jin H., Yang, Victor C.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849409/
https://ncbi.nlm.nih.gov/pubmed/23973813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2013.08.016
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