The Role of Cdk5 in Neuroendocrine Thyroid Cancer

Medullary thyroid carcinoma (MTC) is a neuroendocrine cancer that originates from calcitonin-secreting parafollicular cells, or C cells. We found that Cdk5 and its cofactors, p35 and p25, are highly expressed in human MTC and that Cdk5 activity promotes MTC proliferation. A conditional MTC mouse mod...

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Autors principals: Pozo, Karine, Castro-Rivera, Emely, Tan, Chunfeng, Plattner, Florian, Schwach, Gert, Siegl, Veronika, Meyer, Douglas, Guo, Ailan, Gundara, Justin, Mettlach, Gabriel, Richer, Edmond, Guevara, Jonathan A., Ning, Li, Tsai, Li-Huei, Sun, Xiankai, Antich, Pietro, Sidhu, Stanley, Robinson, Bruce G., Chen, Herbert, Nwariaku, Fiemu E., Pfragner, Roswitha, Richardson, James A., Bibb, James A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849320/
https://ncbi.nlm.nih.gov/pubmed/24135281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.08.027
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