Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells

Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of pathological TAU protein in brains. We report a human neuronal model of tauopathy derived from induced pluripotent stem cells (iPSCs) carrying a TAU-A152T mutation. Using zinc-finger nuclease-mediated g...

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Detaylı Bibliyografya
Asıl Yazarlar: Fong, Helen, Wang, Chengzhong, Knoferle, Johanna, Walker, David, Balestra, Maureen E., Tong, Leslie M., Leung, Laura, Ring, Karen L., Seeley, William W., Karydas, Anna, Kshirsagar, Mihir A., Boxer, Adam L., Kosik, Kenneth S., Miller, Bruce L., Huang, Yadong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2013
Konular:
Report
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849235/
https://ncbi.nlm.nih.gov/pubmed/24319659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.08.001
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