Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells

Tauopathies represent a group of neurodegenerative disorders characterized by the accumulation of pathological TAU protein in brains. We report a human neuronal model of tauopathy derived from induced pluripotent stem cells (iPSCs) carrying a TAU-A152T mutation. Using zinc-finger nuclease-mediated g...

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Main Authors: Fong, Helen, Wang, Chengzhong, Knoferle, Johanna, Walker, David, Balestra, Maureen E., Tong, Leslie M., Leung, Laura, Ring, Karen L., Seeley, William W., Karydas, Anna, Kshirsagar, Mihir A., Boxer, Adam L., Kosik, Kenneth S., Miller, Bruce L., Huang, Yadong
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849235/
https://ncbi.nlm.nih.gov/pubmed/24319659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2013.08.001
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