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Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice

Monoamine oxidase (MAO) A, the major enzyme catalyzing the oxidative degradation of serotonin (5-hydroxytryptamine, 5-HT), plays a key role in emotional regulation. In humans and mice, MAO-A deficiency results in high 5-HT levels, antisocial, aggressive, and perseverative behaviors. We previously sh...

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Detalhes bibliográficos
Main Authors: Bortolato, Marco, Godar, Sean C., Tambaro, Simone, Li, Felix G., Devoto, Paola, Coba, Marcelo P., Chen, Kevin, Shih, Jean C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849223/
https://ncbi.nlm.nih.gov/pubmed/23871843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2013.07.003
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