Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice

Monoamine oxidase (MAO)-A is a key enzyme for the degradation of brain serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). In humans and mice, total MAO-A deficiency results in high 5-HT and NE levels, as well as elevated reactive aggression. Here we report the generation of MAO-A(Neo) mi...

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Autors principals: Bortolato, Marco, Chen, Kevin, Godar, Sean C, Chen, Gao, Wu, Weihua, Rebrin, Igor, Farrell, Mollee R, Scott, Anna L, Wellman, Cara L, Shih, Jean C
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230491/
https://ncbi.nlm.nih.gov/pubmed/21832987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.157
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