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Monomeric rhodopsin is the minimal functional unit required for arrestin binding*
We have tested if arrestin binding requires the G protein-coupled receptor (GPCR) be a dimer or multimer. To do this, we encapsulated single rhodopsin molecules into nanoscale phospholipids particles (so called nanodiscs) and measured their ability to bind arrestin. Our data clearly show that both v...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3848883/ https://ncbi.nlm.nih.gov/pubmed/20417217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.04.029 |
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