[(18) F]FDG-PET imaging is an early non-invasive pharmacodynamic biomarker for a first-in-class dual MEK/Raf inhibitor, RO5126766 (CH5126766), in preclinical xenograft models

BACKGROUND: Positron emission tomography (PET) with [2-(18) F]-2-fluoro-2-deoxy-D-glucose ([(18) F]FDG-PET) was acquired at multiple time-points a) to monitor the early response to RO5126766 (CH5126766) in xenograft models b) to evaluate non-invasive small animal [(18) F]FDG-PET imaging as a biomark...

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Bibliographic Details
Main Authors: Tegnebratt, Tetyana, Lu, Li, Lee, Lucy, Meresse, Valerie, Tessier, Jean, Ishii, Nobuya, Harada, Naoki, Pisa, Pavel, Stone-Elander, Sharon
Format: Artigo
Language:Inglês
Published: Springer 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848680/
https://ncbi.nlm.nih.gov/pubmed/24041012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-3-67
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