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[(18) F]FDG-PET imaging is an early non-invasive pharmacodynamic biomarker for a first-in-class dual MEK/Raf inhibitor, RO5126766 (CH5126766), in preclinical xenograft models
BACKGROUND: Positron emission tomography (PET) with [2-(18) F]-2-fluoro-2-deoxy-D-glucose ([(18) F]FDG-PET) was acquired at multiple time-points a) to monitor the early response to RO5126766 (CH5126766) in xenograft models b) to evaluate non-invasive small animal [(18) F]FDG-PET imaging as a biomark...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3848680/ https://ncbi.nlm.nih.gov/pubmed/24041012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-219X-3-67 |
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