Silencing of HIF Prolyl-Hydroxylase 2 Gene in the Renal Medulla Attenuates Salt-Sensitive Hypertension in Dahl S Rats

BACKGROUND: In response to high salt intake, transcription factor hypoxia-inducible factor (HIF) 1α activates many antihypertensive genes, such as heme oxygenase 1 (HO-1) 1 and cyclooxygenase 2 (COX-2) in the renal medulla, which is an important molecular adaptation to promote extra sodium excretion...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhu, Qing, Hu, Junping, Han, Wei-Qing, Zhang, Fan, Li, Pin-Lan, Wang, Zhengchao, Li, Ningjun
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848632/
https://ncbi.nlm.nih.gov/pubmed/24190904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ajh/hpt207
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