Molecular-guided therapy predictions reveal drug resistance phenotypes and treatment alternatives in malignant peripheral nerve sheath tumors

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNST) are rare highly aggressive sarcomas that affect 8-13% of people with neurofibromatosis type 1. The prognosis for patients with MPNST is very poor. Despite TOP2A overexpression in these tumors, doxorubicin resistance is common, and the mech...

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Detalhes bibliográficos
Main Authors: Peacock, Jacqueline D, Cherba, David, Kampfschulte, Kevin, Smith, Mallory K, Monks, Noel R, Webb, Craig P, Steensma, Matthew
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848568/
https://ncbi.nlm.nih.gov/pubmed/24040940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-213
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