Translating Dosage Compensation to Trisomy 21

Down syndrome (DS) is a common disorder with enormous medical and social costs, caused by trisomy for chromosome 21 (Chr21). We tested the concept that gene imbalance across an extra chromosome can be de facto corrected by manipulating a single gene, XIST. Using genome editing with zinc finger nucle...

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Detalhes bibliográficos
Main Authors: Jiang, Jun, Jing, Yuanchun, Cost, Gregory J., Chiang, Jen-Chieh, Kolpa, Heather J., Cotton, Allison M., Carone, Dawn M., Carone, Benjamin R., Shivak, David A., Guschin, Dmitry Y., Pearl, Jocelynn R., Rebar, Edward J., Byron, Meg, Gregory, Philip D., Brown, Carolyn J., Urnov, Fyodor D., Hall, Lisa L., Lawrence, Jeanne B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3848249/
https://ncbi.nlm.nih.gov/pubmed/23863942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12394
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