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A regulator that inhibits transcription by targeting an intersubunit interaction of the RNA polymerase holoenzyme

The structures of the bacterial RNA polymerase holoenzyme have provided detailed information about the intersubunit interactions within the holoenzyme. Functional analysis indicates that one of these is critical in enabling the holoenzyme to recognize the major class of bacterial promoters. It has b...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gregory, B. D., Nickels, B. E., Garrity, S. J., Severinova, E., Minakhin, L., Bieber Urbauer, R. J., Urbauer, J. L., Heyduk, T., Severinov, K., Hochschild, A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384785/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15070756/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400923101
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