Distinct global shifts in genomic binding profiles of limb malformation-associated HOXD13 mutations

Gene regulation by transcription factors (TFs) determines developmental programs and cell identity. Consequently, mutations in TFs can lead to dramatic phenotypes in humans by disrupting gene regulation. To date, the molecular mechanisms that actually cause these phenotypes have been difficult to ad...

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Main Authors: Ibrahim, Daniel M., Hansen, Peter, Rödelsperger, Christian, Stiege, Asita C., Doelken, Sandra C., Horn, Denise, Jäger, Marten, Janetzki, Catrin, Krawitz, Peter, Leschik, Gundula, Wagner, Florian, Scheuer, Till, Schmidt-von Kegler, Mareen, Seemann, Petra, Timmermann, Bernd, Robinson, Peter N., Mundlos, Stefan, Hecht, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847778/
https://ncbi.nlm.nih.gov/pubmed/23995701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.157610.113
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