The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: A potent sodium-channel blocker

Bufonid anurans of the genus Atelopus contain both steroidal bufadienolides and various guanidinium alkaloids of the tetrodotoxin class. The former inhibit sodium-potassium ATPases, whereas the latter block voltage-dependent sodium channels. The structure of one guanidinium alkaloid, zetekitoxin AB,...

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Detalhes bibliográficos
Main Authors: Yotsu-Yamashita, Mari, Kim, Yong H., Dudley, Samuel C., Choudhary, Gaurav, Pfahnl, Arnold, Oshima, Yasukatsu, Daly, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC384749/
https://ncbi.nlm.nih.gov/pubmed/15070720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400368101
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