Regulation of cell survival by sphingosine-1-phosphate receptor S1P(1) via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Although the ability of bioactive lipid sphingosine-1-phosphate (S1P) to positively regulate anti-apoptotic/pro-survival responses by binding to S1P(1) is well known, the molecular mechanisms remain unclear. Here we demonstrate that expression of S1P(1) renders CCL39 lung fibroblasts resistant to ap...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Rutherford, C, Childs, S, Ohotski, J, McGlynn, L, Riddick, M, MacFarlane, S, Tasker, D, Pyne, S, Pyne, N J, Edwards, J, Palmer, T M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2013
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847331/
https://ncbi.nlm.nih.gov/pubmed/24263101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.455
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars