Regulation of cell survival by sphingosine-1-phosphate receptor S1P(1) via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1

Although the ability of bioactive lipid sphingosine-1-phosphate (S1P) to positively regulate anti-apoptotic/pro-survival responses by binding to S1P(1) is well known, the molecular mechanisms remain unclear. Here we demonstrate that expression of S1P(1) renders CCL39 lung fibroblasts resistant to ap...

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Main Authors: Rutherford, C, Childs, S, Ohotski, J, McGlynn, L, Riddick, M, MacFarlane, S, Tasker, D, Pyne, S, Pyne, N J, Edwards, J, Palmer, T M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847331/
https://ncbi.nlm.nih.gov/pubmed/24263101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.455
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